Back in October, I told you about some exciting research that showed how the spice turmeric can help repair the damage done by strokes and Alzheimer's. At the time, the researchers weren't sure why turmeric worked. I believe it's because of turmeric's powerful anti-inflammatory abilities. As you'll see, there's plenty of evidence to draw this conclusion — and it looks like there may be another nutrient that can help as well.
As you may know, one of the characteristics of Alzheimer's disease is deposits of beta amyloid plaque. But why does the plaque build up in the first place? I've suspected that the cause was similar to why cholesterol builds up in the arteries — inflammation. Without inflammation, the cholesterol flows through the blood vessels without any problems. And, according to the researchers in this new study, the same could be true of beta amyloid. They said, "Numerous biochemical events, leading to beta amyloid neurotoxicity in Alzheimer's disease, have been proposed and it seems that neuroinflammation plays a prominent role among these."
But inflammation isn't the only reason. After all, we have to know why there's inflammation. As you may know, inflammation is the body's way of healing injuries. When you suffer a sprained ankle or knee, the joint becomes inflamed. This is how the body heals. So when there's inflammation, we have to think injury. And the injury that commonly causes inflammation in the blood vessels is oxidative stress. Oxidative stress occurs when there are too many free radicals in your system — or they're out of balance — and your body doesn't handle them properly.
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So the researchers in this study wanted to find out if the recognized antioxidant flavonoid luteolin coupled with an anti-inflammatory nutrient could help reduce beta amyloid deposits. They used a proprietary blend of luteolin and the compound palmitoylethanolamide called co-ultraPEALut. However, you could use any anti-inflammatory, including turmeric.
The researchers tested the compound on both in vitro and ex vivo organotypic models of Alzheimer's disease. For the in vitro model, they used human neuronal cells. They pretreated these cells with the compound for two hours. Then they introduced beta amyloid to the cells. After 24 hours, they evaluated the vitality of the cells. They did a similar type of preparation using hippocampal slice cultures for the organotypic model of Alzheimer's disease.
What they found was impressive. They said, "Pre-treatment with co-ultraPEALut significantly reduced inducible nitric oxide synthase and glial fibrillary acidic protein expression, restored neuronal nitric oxide synthase and brain derived neurotrophic factor and reduced the apoptosis. Taken together our results clearly showed that co-ultraPEALut is able to blunt beta amyloid-induced astrocyte activation and to exert a marked protective effect on glial cells. These findings suggest that the association of co-ultraPEALut may provide an effective strategy for Alzheimer's disease."
While there are several studies on co-ultraPEALut, I have yet to find a way to buy it. If you find one, please let me know. But there is another option. You could simply take Advanced Memory Formula, which contains luteolin, and Reduloxin, which contains turmeric. The antioxidant effects of the luteolin (coupled with the other memory-enhancing nutrients) along with the anti-inflammatory effects of the turmeric could help prevent, slow, and perhaps even reverse some cases of Alzheimer's.
Your insider for better health,
Steve Kroening is the editor of Nutrient Insider, a twice-a-week email newsletter that brings you the latest healing breakthroughs from the world of nutrition and dietary supplements. For over 20 years, Steve has worked hand-in-hand with some of the nation's top doctors, including Drs. Robert Rowen, Frank Shallenberger, Nan Fuchs, William Campbell Douglass, and best-selling author James Balch. Steve is the author of the book Practical Guide to Home Remedies. As a health journalist, Steve's articles have appeared in countless magazines, blogs, and websites.