I don't think I ever heard my father say a cuss word. The closest he ever came was about a year before he died. He had grown very frail. He couldn't get around like he wanted. He couldn't play golf anymore. And he required constant help from his family. We were getting out of the car one day and he turned to me and said, "You know, getting old is h-e-double-hockey-sticks." My dad was always smiling. So when he said that, I knew his frailty had robbed him of many of life's joys.
Seeing my dad and many of my in-home care clients suffer with frailty, I've spent a lot of time and energy looking for ways to beat it. Prevention is obviously the best way to avoid it. Exercise, eating well, socializing, and having purpose are vital. But what can you do if frailty has already set in?
Researchers from the Mayo Clinic Robert and Arlene Kogod Center on Aging asked the same questions. James Kirkland, M.D., Ph.D., director of the center and the lead author of the resulting study, said, "One of the things we want to do is find some kind of treatment for this other than prescribing better wheelchairs or walkers, or other kinds of things that we are stuck with now that are Band-Aid solutions." Once frailty sets in, it rarely has a good outcome and usually brings functional disability.
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Dr. Kirkland and his center are focused on finding a drug to help with frailty. He said, "Our goal is not necessarily to increase life span, and certainly not life span at all costs. Our goal is to enhance health span – the period during life when people are independent." Our goal in home care was to help people remain as independent as possible for as long as possible. But I've never seen a drug that helps with frailty. Most drugs make it worse. In fact, many of my clients' trips to the doctor were to adjust their medications because they were making them feel worse.
Going into the study, Dr. Kirkland and his team knew that chronic inflammation is a major cause of frailty and age-related diseases. In fact, it's a definite hallmark of aging. So they gave Janus kinase (JAK) inhibitors. These are drugs that block the activity of JAK enzymes. And these enzymes decreased the factors released by human senescent cells. Senescent cells are known contributors to frailty and diseases associated with aging. What's more, these same JAK inhibitors reduced inflammation in the mice.
But what was the functional result? After two months of reducing the inflammation and the JAK enzymes, the frail mice had substantial improvement in their physical function. This included their grip strength, endurance, and physical activity.
The researchers said that inhibiting these key enzyme pathways reduced inflammation and frailty in the aged mice and may have the same results in humans. This is all preliminary work, so we don't know for sure what will work in humans.
However, there is some evidence that you can begin to see these same results by taking nutrients. But you'll have to take two nutrient combinations. The first formula is Advanced Natto Formula, which has shown some effectiveness with JAK (though it hasn't been studied much). The second formula is Reduloxin, which is a proven inflammation fighter. It makes sense that taking both of these formulas will help with frailty. The nattokinase will help your blood flow better without fear of blood clots. And reducing inflammation is a key to staying active. So don't wait for the drugs to fight frailty. Try these two formulas and let me know how they work for you. Also make sure you get as much safe activity as you can.
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