New research concludes that NR and resveratrol together could be an anti-aging powerhouse combination. Researchers said taking high doses of resveratrol and NR could "reinvigorate mitochondria and ward off diseases of aging."
"Getting old is H-E-double-hockey-sticks." That's the closest thing to a cuss word I ever heard my dad say. So I knew it had to be true. Aging took its toll on him. It takes a toll on all of us at some point. But new research is suggesting that it doesn't have to be H-E-double-hockey-sticks for all of us.
That's because researchers have found what they're calling "the linchpin of energy metabolism." And it's making huge waves in the anti-aging research community. This "linchpin" is a molecule called nicotinamide adenine dinucleotide or NAD. When your body doesn't have enough NAD, the mitochondria in your cells begin to deteriorate. As you might imagine, your body doesn't produce as much NAD as you get older. Since your mitochondria produce energy, a drop in NAD naturally causes a drop in your energy levels.
NAD first came to prominence in 2013 when a research team from Harvard was able to restore the energy levels of mice to their youthful levels in just one week. They did this by injecting the rodents with NMN (nicotinamide mononucleotide), a molecule that naturally occurs in cells. When they gave the mice the injections, the researchers noticed a dramatic increase in the NAD molecule. They began to wonder if this molecule was the long sought after Fountain of Youth.
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There aren't any NMN supplements readily available. So companies looked for another NAD precursor and found nicotinamide riboside or NR. NR isn't new. Scientists have known about it for well over 60 years. And I told you about its ability to increase NAD last year. That's when the company ChromaDex announced that it had connected NR to NAD in a study paid for by the company. ChromaDex claimed that "a single dose of NR resulted in statistically significant increases" in NAD in humans. This was the first time any study showed that a supplement could really boost NAD levels in people.
But here's where this gets really interesting. One of the reasons this study caught my attention is because it's the same research team that discovered resveratrol has a similar effect on the body as a calorie-restricted diet. This is another study I told you about last year. In that study, the researchers discovered that resveratrol, like calorie restriction, revs up the sirtuin enzyme SIRT1. This enzyme protects mice and humans from the ill effects of a high-fat diet. So by taking high doses of resveratrol, you get the same aging protection as restricting your calories. Well, it turns out that all of this ties into the NAD findings.
Resveratrol isn't the only thing that fuels SIRT1 enzyme. NAD also boosts the activity of all the sirtuin enzymes, including SIRT1. The more NAD you have in your cells, the more SIRT1 protects you against aging. NAD does a lot more than just boost the formation of new mitochondria. It also helps keep those mitochondria running smoothly.
All of this led the researchers to conclude that NAD and resveratrol together could be an anti-aging powerhouse. They said taking high doses of resveratrol and boosting NAD levels could "reinvigorate mitochondria and ward off diseases of aging." As I told you last year, you can find NR supplements online and in some health food stores. And you can find resveratrol and other powerful anti-aging polyphenols in Advanced Polyphenol Formula
. Together, they could change the way you experience aging. Instead of cursing it, you might enjoy it more..
Your insider for better health,
Steve Kroening, ND